Erythritol’s Dirty Little Secret!? 😱 | Educational Video | Dr. Layne Norton Phd

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A recent study (PMID: 40459966) sent the media into a frenzy jumping to conclusions that Erythritol damages brain & vascular cells & will lead to a stroke! There are so many problems with the conclusions by the media & social media from this study but let’s start with the big ones:

This was an in vitro study, meaning in a petri dish. If you think animal studies have limited application then in vitro studies have REALLY limited application
The study exposed brain & vascular cells to 6mM Erythritol for 24 hours & saw increased levels of oxidative stress. They said this corresponded to a 30g dose of Erythritol. MAJOR RED FLAG. 25g of Erythritol barely raised blood levels above 3mM at a PEAK. Even 50g of Erythritol did not reach 6mM at a PEAK (PMID: 36077269). Not only did these massive doses not reach 6mM they claimed, but they came back close to baseline after just a few hours. MASSIVE difference in exposure of a few hours not even close to 6mM vs. 24 hours consistently at this dose
I am aware of no beverages that contain 30g of Erythritol. Most are between 5-18g
Only ~15% of Erythritol in the blood gets to the brain (PMID: 8933634)

So let’s do some quick math. You’d likely need more than 60g of Erythritol at a sitting to even peak out levels at 6mM in the blood. And you’d need to consume them every 3 hours to maintain those levels. That would be 480g Erythritol in a day. Then consider that ONLY 15% gets into the brain. So you still aren’t getting 6mM concentration in the brain, god knows how much you’d need to achieve that. If we just do very linear math (we can’t assume this but we have to guess) we can think about 480g would be 15% of what number? 3200g of Erythritol over 24 hours. Hundreds of times the normal dose. ‘Physiological dose’ my ass. And this is probably honestly undershooting it because it assumes that simply assumes linear math & typically absorption kinetics start to cap out, so this dosage in brain cells may not even be physiologically possible even if you pumped in as much erythritol as possible

Finally Erythritol is associated with cardiovascular disease because people with CVD have overactive pentose phosphate pathway & produce more erythritol endogenously compared to healthy people. That is, they have elevated erythritol in their blood because they have CVD, NOT because erythritol definitely causes CVD

The media & social media influencers should be ashamed for their overreactions & BS

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