Methylation | The Best Kept Optimal Health Secret

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In today’s solo episode, Gary takes you through his career journey from assessing mortality risk for life insurance companies to starting a wellness franchise. He’ll share his experiences applying his knowledge of biomarkers and genetics to treat patients by looking at the root causes of disease. He’ll discuss his decades of research, striving to add not just years to your life but life to your years. He’ll also explore the role of gene mutations and nutrient deficiencies, focusing on the MTHFR gene mutation that affects up to 44% of the population and the impact it has on our body’s ability to convert folic acid into methylfolate. He discusses the wide range of issues a deficiency in methylation can lead to, including anxiety, depression, and poor gut health. Listen in as we unravel the effects of a gene mutation called COMT on conditions like high blood pressure, hypothyroidism, hypercholesterolemia, and estrogen dominance. Learn how nutrient deficiencies can be the cause of common ailments, and how supplementing with the right nutrients can help restore things like estrogen balance. Join us on this journey towards becoming an Ultimate Human.

Additional Topics Covered Include: Anxiety, ADD, ADHD, OCD, Gut Health, and Brain Fog

The 2 Ingredients to Avoid In Your Supplements: Folic Acid and Cyanocobalamin


(0:00:00) – The Ultimate Human

(0:10:45) – Discovering Gene Mutations and Nutrient Deficiencies

(0:22:05) – The Role of Methylation in Health

(0:28:20) – The 2 Ingredients to Avoid in Your Supplements

(0:29:43) – Gene Mutation and Hormonal Imbalance Solution

(0:35:38) – Improving Health Through Natural Practices


Associations of Depressive and Anxiety Symptoms with 24-hour Urinary Catecholamines in individuals with untreated high blood pressure: [] []

MTR and MTRR Genes: Methylation cycle and the need for Vitamin B12: [] []

Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice: [] []

Mitochondrial translation requires folate-dependent tRNA methylation: [] []

MTR and MTRR Genes: Methylation cycle and the need for Vitamin B12: [] []

On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis: [] []

The Ultimate Human podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

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