Paul pulls up a study that compared sucralose sweetened beverage to a sugar sweetened beverage vs. water in terms of hypothalamic blood flow (tends to increase when people are hungrier) & subjective ratings of hunger (PMID: 40140714). The study found that people who drank the sucralose sweetened beverage had increased hypothalamic blood flow & greater ratings of hunger compared to a sugar sweetened beverage. This means that sucralose is going to make you eat more & make you fat right? Not really… let me drop some science on you
1st off, these are all short term measures & mechanistic data & not actual outcomes. 2nd off, it is NOT surprising that sucralose increased hunger relative to sucrose… IT HAS NO CALORIES BUT SUCROSE DOES! Of course the actual calorie containing beverage will dampen hunger more than a non-caloric beverage. But why did Paul not talk about the results of sucralose compared to water? There were NO SIGNIFICANT DIFFERENCES BETWEEN SUCRALOSE SWEETENED BEVERAGE VS. WATER LOL
Finally, & most importantly, the ACTUAL LONG TERM HUMAN RANDOMIZED CONTROLLED TRIALS where people consume beverages containing artificial sweeteners (ASB) like sucralose in place of sugar sweetened beverages (SSB), people LOSE significant weight (PMIDs: 35285920 & 32216045) & they even lose more weight with ASB compared to water as a replacement for SSBs (PMID: 37794246)
Hmm… wonder why Paul didn’t mention those studies?
While this data is interesting, shouldn’t we care MORE about the actual long term, hard outcome data????
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