Study Deep Dive: Creatine is SAFE | Episode 13

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Creatine is SAFE, the verdict is in!

After decades of people claiming that creatine will wreck your kidneys, liver, & various other claims, a new study has put these myths to bed.

In my latest episode of the Dr. Layne Norton Podcast, I go DEEP on the most comprehensive dataset to date: a brand new meta-analysis by Kreider et al. (2025) which reviewed 250+ studies, covering over 26,000 participants, some lasting more than a decade, and examined nearly 50 potential side effects.

The verdict? Absolutely no evidence of harm.

I broke down the full paper, the methods, and what this means for athletes and everyday lifters in the latest episode of the podcast.

*SPONSORS*
• Outwork Nutrition – Evidence-Based Supplements to Support Your Hard Work: https://outworknutrition.com
• REPS Research Review: https://biolayne.com/reps

*LAYNE’S COMPANIES*
Carbon Diet Coach: https://joincarbon.com/podcast
Outwork Nutrition: https://outworknutrition.com
REPS Research Review: https://biolayne.com/reps
Workout Builder: https://biolayne.com/workout-builder
Team Biolayne: https://biolayne.com/online-coaching
Physique Coaching Academy: https://physiquecoachingacademy.com

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*TIMESTAMPS*
0:00:00 – Intro
0:01:33 – Meta Analysis Overview
0:02:14 – Creatine is NOT a Steroid
0:03:10 – ATP
0:05:13 – Creatine from Body and Food
0:06:05 – Creatine Non-Responders
0:06:27 – Creatine Dose
0:07:10 – Creatine Benefits
0:10:18 – Outwork Nutrition
0:11:46 – Interesting Associations
0:13:48 – Safety Questions
0:15:03 – Importance of Placebo
0:17:05 – Study Methods
0:20:05 – Study Results
0:26:08 – REPS Research Review
0:26:57 – Hair Loss
0:29:04 – Creatine is Safe and Effective
0:30:54 – Types of Creatine
0:36:54 – Creatine for Kids
0:38:50 – Recommendations
0:39:39 – Outro

*SHOW NOTES*
https://biolayne.com/podcasts/dr-layne-norton-podcast/

*DISCLAIMER*
This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions.

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